adrenate (22:4n6) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.142
Position:
102075479
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
11.355
Reference Allele:
G
-log10(P):
-67.130
MAF:
0.176
Beta (Num):
0.014
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174549

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.191
Position:
61571382
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
-18.562
Reference Allele:
G
-log10(P):
-175.422
MAF:
0.304
Beta (Num):
-0.182
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.009
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio of adrenate to palmitoleate likely reflects the balance between the synthesis of long-chain polyunsaturated fatty acids via FADS enzymes and monounsaturated fatty acid production.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 affect the efficiency of polyunsaturated fatty acid synthesis, including adrenate.7[1], 8[2], 9[3] This altered lipid metabolism is associated with an increased risk of dyslipidemia, atherosclerosis, and type 2 diabetes, which are observed as associated phenotypes.10[4], 11[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data