adrenate (22:4n6) to palmitate (16:0)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.180
Position:
61588305
SE (Ratio):
0.009
Effect Allele:
G
Z-score (Ratio):
-19.211
Reference Allele:
A
-log10(P):
-187.706
MAF:
0.344
Beta (Num):
-0.181
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.001
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.6[1], 7[2]

Denominator Metabolite Explanation:

De novo lipogenesis, Fatty acid elongation.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio of adrenate (22:4n6) to palmitate (16:0) reflects the efficiency of converting precursor fatty acids into long-chain polyunsaturated fatty acids by FADS enzymes.1[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in FADS1/FADS2 alter polyunsaturated fatty acid synthesis, affecting the adrenate to palmitate ratio. This dysregulation of lipid metabolism is linked to an increased risk of inflammatory conditions like inflammatory bowel disease and metabolic disorders such as cholelithiasis.11[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data