adrenate (22:4n6) to nonadecanoate (19:0)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of nonadecanoate (19:0)
Metabolite Accession: GCST90200451
Name: nonadecanoate (19:0)
Hmdb Id: HMDB0000772
Super Pathway: NA
Sub Pathway: NA
Inchikey: ISYWECDDZWTKFF

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.194
Position:
61592362
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-14.172
Reference Allele:
A
-log10(P):
-103.311
MAF:
0.345
Beta (Num):
-0.177
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.017
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2]

Ratio Explanation:

The ratio reflects fatty acid desaturase (FADS) activity, indicating the conversion rate of dietary fatty acids into long-chain polyunsaturated fatty acids like adrenate.1[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters fatty acid desaturase activity, which modifies the balance of polyunsaturated fatty acids.9[1], 10[2] This dysregulation of lipid metabolism and inflammatory precursors contributes to phenotypes like cholelithiasis, metabolic disorders, and inflammatory skin conditions such as follicular cysts.10[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data