adrenate (22:4n6) to pentadecanoate (15:0)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.197
Position:
61596633
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
-15.514
Reference Allele:
C
-log10(P):
-123.308
MAF:
0.346
Beta (Num):
-0.178
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.018
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty acid metabolism

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2 enzymes.4[1], 5[2], 2[3], 3[4] Higher FADS activity leads to increased adrenate production relative to pentadecanoate, an odd-chain saturated fatty acid.6[5], 7[6], 8[7]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 are linked to altered enzyme activity, affecting the adrenate to pentadecanoate ratio.9[1], 10[2], 11[3] This altered fatty acid profile is associated with an increased risk for cholelithiasis and dyslipidemia, likely through effects on cholesterol metabolism and inflammation.12[4], 13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data