docosatrienoate (22:3n3) to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.496
Position:
61581764
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
21.821
Reference Allele:
T
-log10(P):
-241.381
MAF:
0.342
Beta (Num):
0.233
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.264
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio reflects the balance between omega-3 fatty acid (docosatrienoate) and a glycerophosphoinositol containing the omega-6 fatty acid arachidonic acid, influenced by FADS1 activity.1[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters polyunsaturated fatty acid metabolism, affecting the balance of pro- and anti-inflammatory molecules derived from omega-6 and omega-3 fatty acids, which influences inflammatory conditions like asthma and phlebitis, and also impacts lipid metabolism, contributing to hypercholesterolemia.2[1], 7[2], 8[3], 9[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data