docosatrienoate (22:3n3) to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.307
Position:
61593816
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
17.921
Reference Allele:
C
-log10(P):
-163.694
MAF:
0.372
Beta (Num):
0.226
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.081
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

omega-3 fatty acid biosynthesis

Denominator Metabolite Explanation:

omega-3 fatty acid biosynthesis

Ratio Explanation:

The ratio of docosatrienoate (22:3n3) to DHA (22:6n3) reflects the efficiency of the final steps of omega-3 fatty acid synthesis, where lower FADS2 activity leads to a higher ratio.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS2 activity, indicated by a higher docosatrienoate to DHA ratio, is associated with various inflammatory and metabolic disorders, likely due to its central role in producing pro-resolving versus pro-inflammatory lipid mediators.6[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data