docosatrienoate (22:3n3) to 1,2-dipalmitoyl-gpc (16:0/16:0)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of 1,2-dipalmitoyl-gpc (16:0/16:0)
Metabolite Accession: GCST90199660
Name: 1,2-dipalmitoyl-gpc (16:0/16:0)
Hmdb Id: HMDB0000564
Super Pathway: NA
Sub Pathway: NA
Inchikey: KILNVBDSWZSGLL

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.457
Position:
61581764
SE (Ratio):
0.024
Effect Allele:
C
Z-score (Ratio):
19.342
Reference Allele:
T
-log10(P):
-190.239
MAF:
0.342
Beta (Num):
0.233
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.224
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid metabolism.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phospholipid biosynthesis.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio reflects FADS1-mediated polyunsaturated fatty acid (docosatrienoate) synthesis versus the pool of saturated glycerophospholipids (1,2-dipalmitoyl-gpc), indicating lipid metabolic balance.1[1], 8[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 alter the biosynthesis of PUFAs, which is reflected in the metabolite ratio.9[1] This dysregulation of lipid metabolism and subsequent inflammatory responses contributes to phenotypes like asthma, hypercholesterolemia, and various forms of dermatitis.10[2], 11[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data