docosatrienoate (22:3n3) to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs174544

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.319
Position:
61567753
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
15.576
Reference Allele:
C
-log10(P):
-124.286
MAF:
0.335
Beta (Num):
0.232
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.086
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain polyunsaturated fatty acid biosynthesis6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation9[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects the balance between polyunsaturated fatty acid synthesis (numerator) and fatty acid beta-oxidation (denominator), influenced by FADS1/FADS2 activity.1[1], 12[2], 9[3], 13[4], 14[5]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 gene variants influence the synthesis of docosatrienoate and are associated with altered lipid profiles and inflammation, which are linked to phenotypes like hypercholesterolemia, cholelithiasis, and asthma.15[1], 16[2], 17[3], 18[4], 19[5], 20[6], 21[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data