docosatrienoate (22:3n3) to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.374
Position:
61581764
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
24.485
Reference Allele:
T
-log10(P):
-303.172
MAF:
0.342
Beta (Num):
0.233
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.141
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Ratio Explanation:

The ratio of docosatrienoate (22:3n3) to docosapentaenoate (22:5n3) reflects the efficiency of FADS2, which is involved in the desaturation of PUFAs.4[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variations in FADS2 can alter polyunsaturated fatty acid metabolism, influencing lipid profiles and the risk for inflammatory conditions and cholelithiasis (gallstones), a disease linked to abnormal lipid metabolism and bile composition.6[1], 7[2], 8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data