docosatrienoate (22:3n3) to myristoleate (14:1n5)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.279
Position:
61595564
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
14.296
Reference Allele:
C
-log10(P):
-105.075
MAF:
0.201
Beta (Num):
0.278
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-1.86e-04
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis4[1], 5[2]

Ratio Explanation:

The ratio reflects the balance between long-chain omega-3 PUFA synthesis and shorter-chain fatty acid levels, influenced by FADS desaturase activity.6[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter desaturase activity, impacting the balance of pro- and anti-inflammatory fatty acids, which is associated with inflammatory conditions like asthma and dermatitis.6[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data