docosatrienoate (22:3n3) to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs968567

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.280
Position:
61595564
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
14.591
Reference Allele:
C
-log10(P):
-109.354
MAF:
0.201
Beta (Num):
0.278
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.002
SE (Den):
0.019
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain polyunsaturated fatty acid biosynthesis.5[1]

Denominator Metabolite Explanation:

a-linolenic acid metabolism; y-linolenic acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects the conversion of linolenate (the precursor) to docosatrienoate (a downstream product), a process mediated by the FADS gene cluster.9[1], 10[2], 11[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster, particularly FADS2, alter the efficiency of polyunsaturated fatty acid metabolism.12[1], 13[2] This impacts the balance of pro-inflammatory and anti-inflammatory molecules, potentially leading to chronic inflammatory conditions like sinusitis, asthma, and dermatitis, and affecting lipid and blood cell parameters.12[3]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data