docosatrienoate (22:3n3) to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.493
Position:
61596633
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
23.216
Reference Allele:
C
-log10(P):
-272.861
MAF:
0.379
Beta (Num):
0.225
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.268
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Endocannabinoid and arachidonic acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects the balance between omega-3 (docosatrienoate) and omega-6/endocannabinoid (1-arachidonylglycerol) pathways, both governed by FADS enzyme activity.1[1], 5[2], 7[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

FADS gene variants alter the balance of omega-3/omega-6 fatty acids, impacting inflammation and lipid metabolism.9[1], 10[2] This contributes to phenotypes like cholelithiasis, asthma, and altered cholesterol, all strongly associated with FADS function.11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data