docosatrienoate (22:3n3) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174544

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.299
Position:
61567753
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
15.086
Reference Allele:
C
-log10(P):
-116.743
MAF:
0.335
Beta (Num):
0.232
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.066
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid (n-3 and n-6) biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.5[1], 6[2]

Ratio Explanation:

The ratio reflects the balance between polyunsaturated fatty acid synthesis (numerator) and fatty acid beta-oxidation (denominator), processes influenced by FADS1 activity.1[1], 2[2], 5[3], 6[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 gene variants influence the balance of pro-inflammatory and anti-inflammatory fatty acids.7[1], 8[2] This altered inflammatory state is linked to phenotypes like asthma, dermatitis, and lipid metabolism disorders, with some evidence also pointing to a role in cholelithiasis.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data