docosatrienoate (22:3n3) to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.335
Position:
61593816
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
20.839
Reference Allele:
C
-log10(P):
-220.400
MAF:
0.372
Beta (Num):
0.226
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.109
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Omega-6 fatty acid biosynthesis.4[1]

Ratio Explanation:

This ratio reflects the activity of FADS2, which is involved in both omega-3 and omega-6 fatty acid synthesis, indicating the balance between these pathways.5[1], 6[2], 4[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster influence the balance between pro-inflammatory omega-6 and anti-inflammatory omega-3 fatty acids.7[1], 8[2] This imbalance is linked to metabolic and inflammatory conditions like Type 2 diabetes, hypercholesterolemia, and cholelithiasis, which are associated phenotypes.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data