docosatrienoate (22:3n3) to 1-lignoceroyl-gpc (24:0)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Metabolite Accession: GCST90199895
Name: 1-lignoceroyl-gpc (24:0)
Hmdb Id: HMDB0010405
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.369
Position:
61581764
SE (Ratio):
0.025
Effect Allele:
C
Z-score (Ratio):
14.549
Reference Allele:
T
-log10(P):
-108.748
MAF:
0.342
Beta (Num):
0.233
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.136
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.4[1], 5[2]

Ratio Explanation:

The ratio reflects FADS1 activity; docosatrienoate (22:3n3) is a PUFA, and 1-lignoceroyl-GPC (24:0) is a lysophospholipid, both influenced by overall lipid metabolism.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters PUFA synthesis, impacting the balance of pro-inflammatory and pro-resolving lipid mediators derived from these fatty acids.6[1], 7[2] This imbalance is linked to inflammatory conditions like asthma and dyslipidemia, which are among the associated phenotypes.7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data