docosatrienoate (22:3n3) to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.511
Position:
61592362
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
21.930
Reference Allele:
A
-log10(P):
-243.785
MAF:
0.379
Beta (Num):
0.226
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.285
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis, Omega-6 fatty acid metabolism.6[1]

Ratio Explanation:

The ratio likely reflects FADS1 and FADS2 activity, which influences the balance between omega-3 and omega-6 derived lipids that have opposing inflammatory roles.7[1], 8[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1 activity, influenced by genetic factors, likely disrupts the balance of pro- and anti-inflammatory lipids. This dysregulation may contribute to the development of inflammatory conditions such as cholelithiasis and asthma, which are associated phenotypes.10[1], 7[2], 11[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data