docosatrienoate (22:3n3) to hexadecadienoate (16:2n6)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.277
Position:
61595564
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
14.654
Reference Allele:
C
-log10(P):
-110.286
MAF:
0.201
Beta (Num):
0.278
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.002
SE (Den):
0.019
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

long-chain polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

long-chain polyunsaturated fatty acid biosynthesis

Ratio Explanation:

The ratio reflects the efficiency of FADS2-mediated desaturation, where higher values may indicate decreased enzyme activity, affecting the balance of pro-inflammatory and anti-inflammatory lipids.2[1], 3[2], 1[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS2 influence its desaturase activity, altering the balance of n-3 and n-6 fatty acids.1[1], 2[2] This dysregulation is associated with inflammatory conditions like asthma and sinusitis, potentially due to altered levels of pro- and anti-inflammatory lipid mediators derived from these fatty acids.4[3]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data