docosatrienoate (22:3n3) to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs174544

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.263
Position:
61567753
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
14.375
Reference Allele:
C
-log10(P):
-106.217
MAF:
0.335
Beta (Num):
0.232
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.031
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2]

Ratio Explanation:

The ratio reflects FADS-mediated desaturase activity, contrasting long-chain PUFA synthesis (docosatrienoate) with the availability of monounsaturated acylcarnitines (palmitoleoylcarnitine) for energy.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, modifying the balance of PUFAs that serve as precursors to inflammatory mediators.9[1], 10[2] This dysregulation is linked to inflammatory phenotypes like asthma and dermatitis, and it also influences disorders of lipoprotein metabolism.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data