docosatrienoate (22:3n3) to nisinate (24:6n3)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of nisinate (24:6n3)
Metabolite Accession: GCST90200122
Name: nisinate (24:6n3)
Hmdb Id: HMDB0013025
Super Pathway: NA
Sub Pathway: NA
Inchikey: YHGJECVSSKXFCJ

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.382
Position:
61593816
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
17.015
Reference Allele:
C
-log10(P):
-147.814
MAF:
0.372
Beta (Num):
0.226
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.156
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain polyunsaturated fatty acid metabolism.3[1]

Denominator Metabolite Explanation:

Long-chain polyunsaturated fatty acid biosynthesis.4[1], 5[2]

Ratio Explanation:

The ratio of docosatrienoate (22:3n3) to nisinate (24:6n3) likely reflects FADS2 desaturase activity, where a higher ratio could indicate reduced conversion of precursors.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, reflected in the docosatrienoate-to-nisinate ratio, influences the balance of pro-inflammatory and anti-inflammatory fatty acids, potentially contributing to the risk of inflammatory conditions like cholelithiasis and metabolic disorders such as type 2 diabetes through modulation of lipid signaling and inflammation.6[1], 7[2]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data