docosatrienoate (22:3n3) to docosatrienoate (22:3n6)*

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.413
Position:
61551927
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
19.419
Reference Allele:
A
-log10(P):
-191.745
MAF:
0.374
Beta (Num):
0.221
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.192
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid (n-3) biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid (n-6) biosynthesis.7[1], 6[2]

Ratio Explanation:

This ratio reflects the balance between omega-3 (anti-inflammatory) and omega-6 (pro-inflammatory) fatty acid synthesis, which compete for the FADS1 enzyme.8[1], 9[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1 activity influences the docosatrienoate (n-3/n-6) ratio, impacting the balance of pro- and anti-inflammatory eicosanoids, which is associated with inflammatory conditions like asthma and metabolic phenotypes such as hypercholesterolemia and cholelithiasis.10[1], 11[2], 8[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data