docosatrienoate (22:3n3) to arachidonoylcarnitine (c20:4)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.487
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
22.060
Reference Allele:
A
-log10(P):
-246.635
MAF:
0.377
Beta (Num):
0.220
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.267
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 PUFA metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid transport and beta-oxidation, Omega-6 PUFA metabolism.5[1], 6[2]

Ratio Explanation:

This ratio reflects the balance between omega-3 (docosatrienoate) and omega-6 (arachidonoylcarnitine) fatty acid pathways, which are directly influenced by FADS1/FADS2 enzyme activity.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters PUFA balance, impacting inflammatory precursors and lipid mediators.7[1], 9[2] This contributes to inflammatory conditions like asthma and nasal polyps, and metabolic disorders such as cholelithiasis and dyslipidaemia, which are linked to FADS variants.10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data