docosatrienoate (22:3n3) to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs61817724

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.173
Position:
151921111
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
10.190
Reference Allele:
A
-log10(P):
-54.473
MAF:
0.318
Beta (Num):
0.053
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.120
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.298
Position:
61595564
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
15.037
Reference Allele:
C
-log10(P):
-115.993
MAF:
0.201
Beta (Num):
0.278
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.020
SE (Den):
0.019
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.9[1], 10[2], 11[3], 12[4], 13[5]

Ratio Explanation:

This ratio likely reflects FADS2 activity, where higher values suggest increased enzymatic conversion of precursor fatty acids to produce docosatrienoate (22:3n3).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS2 activity, indicated by a lower docosatrienoate to tetradecadienoate ratio, is associated with inflammatory conditions like asthma and sinusitis, potentially through altered eicosanoid production.14[1], 15[2], 16[3], 17[4]

Phenotype Driver:

Gene-centric:FADS2 1216-317-273-271-2077

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data