docosatrienoate (22:3n3) to dodecadienoate (12:2)*

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.326
Position:
61595564
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
15.091
Reference Allele:
C
-log10(P):
-116.820
MAF:
0.201
Beta (Num):
0.278
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.047
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid (n3/n6) biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty Acid, Dicarboxylate metabolism.7[1], 8[2]

Ratio Explanation:

This ratio reflects the efficiency of long-chain polyunsaturated fatty acid synthesis, catalyzed in part by FADS enzymes, relative to a dicarboxylate fatty acid.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants alter desaturase efficiency, impacting LC-PUFA levels.9[1], 10[2] Dysregulated PUFA metabolism affects inflammatory mediators and cell membrane composition, contributing to inflammatory skin conditions like dermatitis, sinusitis, and altered blood lipid/cell profiles.11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data