docosatrienoate (22:3n3) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.274
Position:
61595564
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
15.211
Reference Allele:
C
-log10(P):
-118.636
MAF:
0.201
Beta (Num):
0.278
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.005
SE (Den):
0.019
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain polyunsaturated fatty acid (n-3) biosynthesis.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Palmitic acid metabolism, Omega-7 fatty acid biosynthesis.8[1], 9[2]

Ratio Explanation:

The ratio reflects the balance between omega-3 fatty acid synthesis and de novo lipogenesis, influenced by FADS desaturase activity on different substrates.10[1], 11[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity alters polyunsaturated fatty acid profiles, impacting inflammatory pathways.12[1], 13[2] This dysregulation is linked to inflammatory skin conditions and asthma, and changes in blood lipids and cell counts.14[3], 15[4], 16[5], 17[6]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data