docosatrienoate (22:3n3) to stearate (18:0)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.296
Position:
61595564
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
16.843
Reference Allele:
C
-log10(P):
-144.899
MAF:
0.201
Beta (Num):
0.278
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.017
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain polyunsaturated fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio reflects the activity of fatty acid desaturation and elongation pathways, where FADS enzymes produce long-chain polyunsaturated fatty acids relative to stearate levels.8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid (PUFA) metabolism, reflected by the ratio.8[1], 10[2] This alters the balance of pro-inflammatory and anti-inflammatory lipid mediators, contributing to associations with inflammatory conditions like asthma, dermatitis, and sinusitis.11[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data