docosatrienoate (22:3n3) to palmitate (16:0)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs61897793

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.278
Position:
61599347
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
16.660
Reference Allele:
G
-log10(P):
-141.816
MAF:
0.203
Beta (Num):
0.279
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
9.64e-04
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 FADS3

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.4[1], 5[2]

Ratio Explanation:

This ratio reflects the efficiency of polyunsaturated fatty acid (PUFA) synthesis, where FADS enzymes are central to converting precursor fatty acids to long-chain PUFAs.1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid levels, impacting the balance of inflammatory mediators.6[1], 7[2] This dysregulation is linked to inflammatory conditions like asthma, sinusitis, and dermatitis, which are observed among the associated phenotypes.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data