docosatrienoate (22:3n3) to nonadecanoate (19:0)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of nonadecanoate (19:0)
Metabolite Accession: GCST90200451
Name: nonadecanoate (19:0)
Hmdb Id: HMDB0000772
Super Pathway: NA
Sub Pathway: NA
Inchikey: ISYWECDDZWTKFF

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.283
Position:
61595564
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
14.404
Reference Allele:
C
-log10(P):
-106.639
MAF:
0.201
Beta (Num):
0.278
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.004
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain polyunsaturated fatty acid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects FADS1-mediated synthesis of docosatrienoate (22:3n3) relative to nonadecanoate (19:0), a saturated fatty acid not synthesized via the same pathway.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 activity, reflected in the metabolite ratio, influences the balance of pro-inflammatory and anti-inflammatory lipid mediators.10[1], 11[2], 12[3], 13[4] This dysregulation can contribute to inflammatory conditions like sinusitis and asthma, and also affects blood lipid profiles and cell counts, linking to the associated phenotypes.14[5], 15[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data