docosatrienoate (22:3n3) to margarate (17:0)

Numerator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Denominator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.286
Position:
61595564
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
16.206
Reference Allele:
C
-log10(P):
-134.328
MAF:
0.201
Beta (Num):
0.278
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.008
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Long-chain fatty acid metabolism7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the activity of fatty acid desaturases (FADS1/FADS2) in converting shorter-chain fatty acids to longer-chain polyunsaturated fatty acids like docosatrienoate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS gene cluster influences the metabolism of polyunsaturated fatty acids.1[1], 2[2], 10[3] This altered metabolism is linked to inflammatory and immune-related conditions like asthma and sinusitis11[4], 10[5], and also affects hematological parameters.12[6], 13[7], 14[8], 15[9]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data