docosadienoate (22:2n6) to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of docosadienoate (22:2n6)
Metabolite Accession: GCST90199711
Name: docosadienoate (22:2n6)
Hmdb Id: HMDB0061714
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVGRZDASOHMCSK

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.113
Position:
61593005
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
11.343
Reference Allele:
A
-log10(P):
-66.993
MAF:
0.346
Beta (Num):
-0.025
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.138
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid metabolism

Denominator Metabolite Explanation:

Omega-3 fatty acid metabolism

Ratio Explanation:

The ratio reflects the balance between omega-6 and omega-3 fatty acid synthesis, which is modulated by the competitive enzymatic activity of FADS1 and FADS2.1[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter the balance of omega-6 and omega-3 polyunsaturated fatty acids, impacting lipid profiles and inflammation. This dysregulation is associated with cardiometabolic phenotypes like hypercholesterolemia, type 2 diabetes, and cholelithiasis (gallstone disease), which share lipid metabolism as a common underlying pathology.4[1], 5[2], 6[3], 7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data