docosadienoate (22:2n6) to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of docosadienoate (22:2n6)
Metabolite Accession: GCST90199711
Name: docosadienoate (22:2n6)
Hmdb Id: HMDB0061714
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVGRZDASOHMCSK

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174570

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.172
Position:
61597212
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
9.808
Reference Allele:
C
-log10(P):
-50.614
MAF:
0.131
Beta (Num):
0.010
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
-0.162
SE (Den):
0.023
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Ratio Explanation:

The ratio of docosadienoate to docosapentaenoate (n6 DPA) reflects FADS2 enzyme efficiency in the omega-6 fatty acid pathway.4[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS2 activity, reflected by the docosadienoate to docosapentaenoate ratio, influences the availability of precursors for signaling molecules that can impact inflammatory processes and cell growth, potentially contributing to skin cancer and metabolic changes seen in type 2 diabetes.2[1], 6[2], 7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data