docosadienoate (22:2n6) to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of docosadienoate (22:2n6)
Metabolite Accession: GCST90199711
Name: docosadienoate (22:2n6)
Hmdb Id: HMDB0061714
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVGRZDASOHMCSK

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.136
Position:
151879761
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
10.831
Reference Allele:
G
-log10(P):
-61.267
MAF:
0.318
Beta (Num):
0.013
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.123
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis; omega-6 fatty acid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.6[1]

Ratio Explanation:

Altered `THEM4` activity likely impacts the balance of fatty acid elongation versus termination, thus affecting the ratio of docosadienoate (22:2n6) to tetradecadienoate (14:2).8[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data was provided to establish a link between `THEM4` activity, the docosadienoate to tetradecadienoate ratio, and a clinical outcome.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data