3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf) to xanthurenate

Numerator Metabolite

Structure of 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Metabolite Accession: GCST90199712
Name: 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Hmdb Id: HMDB0061112
Super Pathway: NA
Sub Pathway: NA
Inchikey: WMCQWXZMVIETAO

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
0.209
Position:
25802083
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
10.181
Reference Allele:
T
-log10(P):
-54.383
MAF:
0.445
Beta (Num):
0.102
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.107
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Furanoid fatty acid metabolism, uremic toxin.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Tryptophan metabolism, kynurenine pathway.10[1], 11[2], 12[3]

Ratio Explanation:

This ratio may reflect altered transport activity by SLC17A4, affecting the clearance of CMPF and xanthurenate, both being organic anions and uremic toxins.4[1], 8[2], 13[3], 14[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired SLC17A4 function can decrease the excretion of uric acid and uremic toxins like CMPF, contributing to higher serum creatinine and uric acid levels. The resulting uremic state is associated with hematological abnormalities like decreased hemoglobin and hematocrit.15[1], 16[2]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data