3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf) to n-acetylhistidine

Numerator Metabolite

Structure of 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Metabolite Accession: GCST90199712
Name: 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Hmdb Id: HMDB0061112
Super Pathway: NA
Sub Pathway: NA
Inchikey: WMCQWXZMVIETAO

Denominator Metabolite

Structure of n-acetylhistidine
Metabolite Accession: GCST90199735
Name: n-acetylhistidine
Hmdb Id: HMDB0032055
Super Pathway: NA
Sub Pathway: NA
Inchikey: KBOJOGQFRVVWBH

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.194
Position:
25802083
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
8.823
Reference Allele:
T
-log10(P):
-41.336
MAF:
0.445
Beta (Num):
0.102
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s): Furan fatty acid metabolism.4[1]

Denominator Metabolite Explanation:

Denominator Pathway(s): Histidine metabolism.5[1], 6[2]

Ratio Explanation:

Ratio Interpretation: The ratio may reflect the transport efficiency of SLC17A4, which transports urate, an organic anion, and may also transport CMPF, another organic anion.1[1], 3[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Ratio-Phenotype Link: The SLC17A4 missense variant likely alters transport of anions like urate and CMPF.1[1], 2[2], 7[3] Elevated levels of these uremic solutes are linked to renal dysfunction, which impacts erythropoiesis and can cause anemia, connecting to the observed hematological (MCHC, Hb, Ht) and renal (sCr, Uric acid) phenotypes.7[4], 8[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data