3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf) to 4-allylphenol sulfate

Numerator Metabolite

Structure of 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Metabolite Accession: GCST90199712
Name: 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Hmdb Id: HMDB0061112
Super Pathway: NA
Sub Pathway: NA
Inchikey: WMCQWXZMVIETAO

Denominator Metabolite

Structure of 4-allylphenol sulfate
Metabolite Accession: GCST90199847
Name: 4-allylphenol sulfate
Hmdb Id: HMDB0170765
Super Pathway: NA
Sub Pathway: NA
Inchikey: KFDHKOFCRYUXLA

Associated Genomic Regions

Region: rs1165196

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.187
Position:
25813150
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
9.379
Reference Allele:
A
-log10(P):
-46.454
MAF:
0.445
Beta (Num):
0.101
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.086
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Furanoid fatty acid metabolism.6[1]

Denominator Metabolite Explanation:

Phenylsulfate synthesis from chavicol.7[1], 8[2]

Ratio Explanation:

The ratio may reflect altered transport of CMPF, a uremic toxin, and 4-allylphenol sulfate by SLC17A4, impacting their circulating levels.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant may alter transport of CMPF and other organic anions, including urate.1[1], 9[2] This could influence serum uric acid levels and hematological parameters like MCHC and hemoglobin, which are associated phenotypes, potentially through downstream effects on erythropoiesis or erythrocyte lifespan.10[3]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data