3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf) to n-acetylkynurenine (2)

Numerator Metabolite

Structure of 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Metabolite Accession: GCST90199712
Name: 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Hmdb Id: HMDB0061112
Super Pathway: NA
Sub Pathway: NA
Inchikey: WMCQWXZMVIETAO

Denominator Metabolite

Structure of n-acetylkynurenine (2)
Metabolite Accession: GCST90200015
Name: n-acetylkynurenine (2)
Hmdb Id: HMDB0240342
Super Pathway: NA
Sub Pathway: NA
Inchikey: PPIMFXHQDQRWGJ

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.230
Position:
25802083
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
10.245
Reference Allele:
T
-log10(P):
-55.045
MAF:
0.445
Beta (Num):
0.102
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.128
SE (Den):
0.017
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Furanoid fatty acid metabolism.6[1]

Denominator Metabolite Explanation:

Tryptophan metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect altered transport or metabolism of uremic (CMPF) and tryptophan-derived (N-acetylkynurenine) organic anions, potentially due to SLC17A4 transporter activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant may alter the transport of CMPF and N-acetylkynurenine, affecting their circulating levels. Altered SLC17A4 function is linked to changes in urate and creatinine, which could secondarily influence hematological parameters like MCHC, MCH, and hemoglobin, explaining the observed phenotype associations.1[1], 2[2], 10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data