3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf) to hydroxy-cmpf*

Numerator Metabolite

Structure of 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Metabolite Accession: GCST90199712
Name: 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Hmdb Id: HMDB0061112
Super Pathway: NA
Sub Pathway: NA
Inchikey: WMCQWXZMVIETAO

Denominator Metabolite

Metabolite Accession: GCST90200154
Name: hydroxy-cmpf*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7913269

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.083
Position:
96813932
SE (Ratio):
0.009
Effect Allele:
C
Z-score (Ratio):
9.622
Reference Allele:
T
-log10(P):
-48.795
MAF:
0.282
Beta (Num):
0.006
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.077
SE (Den):
0.017
No CNV overlap
rQTL cluster:
71
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 C10orf129 PDLIM1 CYP2C19

LLM Analysis

Numerator Metabolite Explanation:

Furan fatty acid metabolism4[1]

Denominator Metabolite Explanation:

Furan fatty acid metabolism, hydroxylation5[1]

Ratio Explanation:

This ratio reflects the hydroxylation of CMPF, a reaction likely catalyzed by a CYP2C family enzyme to facilitate clearance. A higher ratio indicates lower enzyme activity.

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variation in the CYP2C gene cluster, which is colocalized with glaucoma, likely alters CYP2C enzyme activity.3[1], 6[2], 7[3] This change in activity affects the CMPF/hydroxy-CMPF ratio, and elevated CMPF is a uremic toxin potentially linked to glaucoma-associated pathologies like optic neuropathy.8[4], 9[5], 10[6]

Phenotype Driver:

Gene-centric:CYP2C9

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data