docosapentaenoate n3 DPA; 22:5n3 to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs3798707

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
0.128
Position:
10991935
SE (Ratio):
0.008
Effect Allele:
T
Z-score (Ratio):
15.458
Reference Allele:
C
-log10(P):
-122.442
MAF:
0.432
Beta (Num):
0.053
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.074
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 SMIM13 GCM2

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid elongation; Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Docosahexaenoic acid biosynthesis3[1]

Ratio Explanation:

The ratio of DPA to DHA reflects the efficiency of the final steps in DHA synthesis, where ELOVL2 plays a key role in elongating DPA.4[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

A lower ELOVL2 activity would lead to an accumulation of the precursor DPA and a decrease in the product DHA, altering the DPA/DHA ratio. Since no specific phenotype is provided, a direct causal link cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data