docosapentaenoate n3 DPA; 22:5n3 to 3-hydroxymyristate

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of 3-hydroxymyristate
Metabolite Accession: GCST90199674
Name: 3-hydroxymyristate
Hmdb Id: HMDB0061656,HMDB0010731
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATRNZOYKSNPPBF

Associated Genomic Regions

Region: rs174548

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.139
Position:
61571348
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
-12.087
Reference Allele:
C
-log10(P):
-75.775
MAF:
0.309
Beta (Num):
-0.143
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.004
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Bacterial quorum sensing, Fatty acid metabolism

Ratio Explanation:

The ratio of docosapentaenoate to 3-hydroxymyristate reflects the activity of FADS enzymes in producing long-chain polyunsaturated fatty acids relative to a bacterial-related fatty acid.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 influence the levels of long-chain polyunsaturated fatty acids.3[1], 4[2], 5[3] Altered levels of these fatty acids are associated with variations in cholesterol and triglycerides, which are linked to hypercholesterolemia and other lipid metabolism disorders.6[4], 7[5], 8[6], 9[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data