docosapentaenoate n3 DPA; 22:5n3 to 3-hydroxydecanoate

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.227
Position:
151879761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
15.887
Reference Allele:
G
-log10(P):
-129.187
MAF:
0.318
Beta (Num):
0.017
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.210
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation6[1], 7[2]

Ratio Explanation:

The ratio may reflect the balance between omega-3 fatty acid availability and mitochondrial medium-chain fatty acid oxidation, potentially modulated by THEM4 thioesterase activity.3[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in THEM4 may alter its thioesterase activity, affecting the balance between long-chain omega-3 fatty acids and medium-chain beta-oxidation intermediates, though phenotypic consequences are not specified.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data