docosapentaenoate n3 DPA; 22:5n3 to myristoleate (14:1n5)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.121
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
8.940
Reference Allele:
G
-log10(P):
-42.392
MAF:
0.176
Beta (Num):
0.024
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.097
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174549

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.155
Position:
61571382
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
-13.865
Reference Allele:
G
-log10(P):
-98.975
MAF:
0.304
Beta (Num):
-0.144
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.011
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

PUFA biosynthesis, Fatty acid metabolism

Denominator Metabolite Explanation:

Monounsaturated fatty acid biosynthesis

Ratio Explanation:

The ratio reflects the enzymatic balance between polyunsaturated (DPA) and monounsaturated (myristoleate) fatty acid synthesis, influenced by FADS1 and SCD activity.1[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1, which regulates PUFA synthesis, are linked to altered lipid profiles and risk for cardiovascular diseases like coronary atherosclerosis and myocardial infarction.4[1], 5[2], 6[3] The ratio likely reflects this altered lipid metabolism contributing to cardiovascular and metabolic phenotypes.

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data