docosapentaenoate n3 DPA; 22:5n3 to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.137
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
9.537
Reference Allele:
G
-log10(P):
-47.973
MAF:
0.176
Beta (Num):
0.024
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174549

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.163
Position:
61571382
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-13.775
Reference Allele:
G
-log10(P):
-97.733
MAF:
0.304
Beta (Num):
-0.144
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.019
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation or elongation.

Ratio Explanation:

The ratio reflects the balance between long-chain polyunsaturated fatty acid synthesis and medium-chain fatty acid levels, influenced by FADS desaturase activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and FADS2 alter desaturase activity, affecting the balance of pro-inflammatory and anti-inflammatory fatty acids.6[1], 7[2] This imbalance is linked to dyslipidemia and increased risk for cardiovascular diseases and type 2 diabetes, phenotypes strongly associated with this ratio.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data