docosapentaenoate n3 DPA; 22:5n3 to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.156
Position:
61592362
SE (Ratio):
0.009
Effect Allele:
G
Z-score (Ratio):
-17.012
Reference Allele:
A
-log10(P):
-147.760
MAF:
0.345
Beta (Num):
-0.136
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.020
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty acid metabolism

Ratio Explanation:

The ratio of DPA to 10-nonadecenoate reflects FADS desaturase activity; a higher ratio indicates greater conversion of precursors to long-chain polyunsaturated n-3 fatty acids.1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, influencing the balance of n-3 and n-9 fatty acids.1[1], 6[2] This altered lipid profile is linked to inflammation and metabolic disturbances underlying phenotypes like dyslipidaemia, asthma, and cardiovascular disease.1[3], 5[4], 7[5], 8[6], 9[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data