docosapentaenoate n3 DPA; 22:5n3 to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.157
Position:
61581764
SE (Ratio):
0.009
Effect Allele:
C
Z-score (Ratio):
-17.192
Reference Allele:
T
-log10(P):
-150.862
MAF:
0.308
Beta (Num):
-0.141
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.016
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.1[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.

Ratio Explanation:

The ratio reflects FADS1 activity; higher FADS1 function leads to increased docosapentaenoate (downstream product) relative to 10-heptadecenoate, impacting inflammatory and metabolic pathways.2[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 genetic variants alter its desaturase activity, influencing the balance of pro-inflammatory and anti-inflammatory polyunsaturated fatty acids. This dysregulation of lipid metabolism is associated with an increased risk for cholelithiasis and hypercholesterolemia, likely due to altered cholesterol and bile acid homeostasis.2[1], 6[2], 7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data