docosapentaenoate n3 DPA; 22:5n3 to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.271
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-11.553
Reference Allele:
C
-log10(P):
-69.413
MAF:
0.339
Beta (Num):
-0.142
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.11[1], 12[2]

Ratio Explanation:

This ratio reflects the activity of FADS-mediated desaturation, where lower FADS function leads to a decrease in the long-chain fatty acid product (DPA) relative to its precursor's incorporation into phospholipids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity, indicated by a lower DPA to linoleoyl-GPC ratio, is associated with altered lipid profiles, including changes in cholesterol and triglycerides.13[1], 14[2] This dyslipidemia is a known risk factor for cholelithiasis and other metabolic and inflammatory conditions.2[3], 5[4], 15[5], 16[6], 17[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data