docosapentaenoate n3 DPA; 22:5n3 to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs174567

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.150
Position:
61593005
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-14.142
Reference Allele:
A
-log10(P):
-102.879
MAF:
0.346
Beta (Num):
-0.138
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.012
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 PUFA synthesis

Denominator Metabolite Explanation:

Omega-3/Omega-6 PUFA synthesis

Ratio Explanation:

This ratio reflects the efficiency of converting the precursor linolenate to the long-chain polyunsaturated fatty acid DPA via the multi-step FADS-mediated pathway.1[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid synthesis, reflected by the DPA/linolenate ratio.4[1], 5[2] This dysregulation of fatty acid metabolism plausibly contributes to phenotypes involving inflammation (dermatitis, asthma), lipid disorders (hypercholesterolaemia, cholelithiasis), and associated cardiovascular diseases like valvular disease and pulmonary embolism.6[3], 7[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data