docosapentaenoate n3 DPA; 22:5n3 to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs3945981

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.110
Position:
11011405
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
9.540
Reference Allele:
G
-log10(P):
-47.995
MAF:
0.426
Beta (Num):
0.052
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.058
SE (Den):
0.016
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 SMIM13 ERVFRD-1

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Omega-6 fatty acid biosynthesis.1[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the balance between competing omega-3 and omega-6 fatty acid synthesis pathways, as ELOVL2 acts on precursors for both n-3 and n-6 DPA.1[1], 9[2], 10[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a causal link between ELOVL2, the docosapentaenoate n3/n6 ratio, and a phenotype cannot be established from the given data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data