docosapentaenoate n3 DPA; 22:5n3 to tetradecanedioate (c14-dc)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.179
Position:
61569830
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-11.478
Reference Allele:
C
-log10(P):
-68.548
MAF:
0.339
Beta (Num):
-0.142
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.037
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation8[1]

Ratio Explanation:

The ratio reflects the balance between n-3 polyunsaturated fatty acid synthesis and dicarboxylic acid levels, with FADS enzymes driving the numerator.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity, influenced by genetic variants, can decrease DPA levels, potentially impacting inflammatory processes and lipid profiles, which are associated with cholelithiasis and dyslipidemia.9[1], 10[2], 11[3] The link between tetradecanedioate and these phenotypes is less clear but may involve alterations in fatty acid oxidation.12[4], 8[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data