docosapentaenoate n3 DPA; 22:5n3 to (16 or 17)-methylstearate (a19:0 or i19:0)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of (16 or 17)-methylstearate (a19:0 or i19:0)
Metabolite Accession: GCST90199887
Name: (16 or 17)-methylstearate (a19:0 or i19:0)
Hmdb Id: HMDB0037397
Super Pathway: NA
Sub Pathway: NA
Inchikey: YETXGSGCWODRAA

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.154
Position:
61592362
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
-13.011
Reference Allele:
A
-log10(P):
-87.437
MAF:
0.345
Beta (Num):
-0.136
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.018
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty acid biosynthesis

Ratio Explanation:

The ratio reflects the balance between omega-3 polyunsaturated fatty acid synthesis and branched-chain fatty acid levels, influenced by FADS desaturase activity.1[1], 4[2], 5[3], 6[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants alter desaturase activity, impacting the balance of pro-inflammatory and anti-inflammatory fatty acids and lipid profiles.4[1], 7[2] This dysregulation is linked to metabolic disorders like hypercholesterolemia, cholelithiasis, and type 2 diabetes, which are observed in the associated phenotypes.8[3], 9[4], 4[5], 10[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data