docosapentaenoate n3 DPA; 22:5n3 to cis-4-decenoate (10:1n6)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.426
Position:
151879761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
27.776
Reference Allele:
G
-log10(P):
-389.293
MAF:
0.318
Beta (Num):
0.017
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.409
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1]

Ratio Explanation:

The ratio reflects competition between omega-3 and omega-6 fatty acid metabolism.7[1], 8[2] THEM4 activity could alter the balance by acting on acyl-CoA precursors.2[3], 3[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data