docosapentaenoate n3 DPA; 22:5n3 to n-oleoyltaurine

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.257
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-15.404
Reference Allele:
C
-log10(P):
-121.600
MAF:
0.208
Beta (Num):
-0.018
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.239
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid amide metabolism / N-acyl taurine degradation.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio likely reflects FAAH-mediated hydrolysis of N-oleoyltaurine (denominator) relative to the background availability of the omega-3 fatty acid DPA (numerator).4[1], 5[2], 6[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype association was provided; therefore, a causal link between the FAAH gene, the metabolite ratio, and a specific phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data